Porter A T
University of Western Ontario, London, Canada.
Prog Clin Biol Res. 1990;353:23-34.
The treatment of muscle invasive bladder cancer still remains controversial. It is becoming more clear, however, that attempts to retain the functional capacity of the urinary bladder by the use of non-surgical methods may be of benefit in the long-term. Studies using radiotherapy in combination with chemotherapeutic agents or intravesicle sensitizers, or the use of radiotherapy alone, but optimized (i.e., brachytherapy and altered fractionation) may be able to achieve improved local control whilst retaining a functional bladder. Attempts to couple this with improved survival due to the sterilization of occult metastases is still subject to much debate.
肌肉浸润性膀胱癌的治疗仍存在争议。然而，越来越清楚的是，通过使用非手术方法试图保留膀胱的功能能力可能从长远来看是有益的。使用放疗联合化疗药物或膀胱内增敏剂的研究，或单独使用放疗但进行优化（即近距离放疗和改变分割方式），可能能够在保留膀胱功能的同时实现更好的局部控制。试图将此与因隐匿性转移灶的清除而提高生存率相结合仍存在诸多争议。
