Bandyopadhyay Ranjana, Sinha Swapan Kumar, Chatterjee Uttara, Nag Dipanwita, Mukhopadhyay Subhalakshmi, Chowdhury Supriyo Roy, Biswas Pranab K
Department of Pathology, Burdwan Medical College, Kolkata, West Bengal, India.
Indian J Med Paediatr Oncol. 2011 Apr;32(2):92-5. doi: 10.4103/0971-5851.89786.
Primary non-Hodgkin's lymphoma (NHL) of the gastrointestinal (GI) tract is the most common extranodal lymphoma in pediatric age group. Yet, the overall incidence is very low. The rarity of the disease as well as variable clinical presentation prevents early detection when the possibility of cure exists.
We studied six cases of primary GI NHL in pediatric age group with reference to their clinical presentation, anatomic distribution and histopathologic characteristics.
All were males except one. Intestinal obstruction was the presenting feature in 50%. Half the cases showed ileocaecal involvement, while large bowel was involved in 16%. Histology showed four cases of diffuse large B-cell lymphoma (DLBCL), one case of Burkitt lymphoma, and one Burkitt-like lymphoma. Immunohistochemistry for Tdt, CD20, CD3, CD30, bcl2, bcl6 confirmed the morphological diagnosis.
Pediatric GI lymphoma commonly involves the ileocaecal region and presents with intestinal obstruction. A higher prevalence of DLBCL is found compared to other series. A high proliferative index is useful in differentiating Burkitt-like lymphoma from DLBCL.
原发性胃肠道非霍奇金淋巴瘤（NHL）是儿童年龄组中最常见的结外淋巴瘤。然而，其总体发病率非常低。该疾病的罕见性以及临床表现的多样性使得在有可能治愈时难以早期发现。
我们研究了儿童年龄组的6例原发性胃肠道NHL病例，涉及其临床表现、解剖分布和组织病理学特征。
除1例为女性外，其余均为男性。50%的病例以肠梗阻为首发症状。半数病例表现为回盲部受累，16%累及大肠。组织学检查显示4例弥漫性大B细胞淋巴瘤（DLBCL）、1例伯基特淋巴瘤和1例伯基特样淋巴瘤。TdT、CD20、CD3、CD30、bcl2、bcl6的免疫组化检查证实了形态学诊断。
儿童胃肠道淋巴瘤常累及回盲部并表现为肠梗阻。与其他系列相比，DLBCL的患病率更高。高增殖指数有助于鉴别伯基特样淋巴瘤和DLBCL。
