Riopel C, Righini M
Service d'Angiologie et d'Hémostase, Hôpitaux Universitaires de Genève, 4 rue Gabrielle-Perret-Gentil, 1211 Genève 14, Suisse.
J Mal Vasc. 2011 Dec;36 Suppl 1:S37-41. doi: 10.1016/S0398-0499(11)70007-5.
The expanded use of multi-detector computed tomography has increased the proportion of diagnosed subsegmental pulmonary embolism. The clinical significance and prognosis of these embolisms remain unknown and the benefit of anticoagulation is not yet proven. Several previously validated diagnostic strategies for pulmonary embolism exclusion (based on single-detector computed tomography and ventilation-perfusion lung scan) were unable to detect most of these subsegmental pulmonary embolisms. However, these strategies have been proven safe, with very few thromboembolic events at 3 months. Furthermore, the comparison between studies using single-detector and multi-detector computed tomography suggests increased rates of PE diagnosis and increased rates of anticoagulated patients without improvement of the three-month followup. Subsegmental pulmonary embolisms seem to have less clinical impact than proximal pulmonary embolisms and a better long-term prognosis. In some patients with isolated subsegmental pulmonary embolism, the bleeding risk related to anticoagulation might outweigh the benefit of preventing recurrent thromboembolic event.
多排螺旋计算机断层扫描(CT)的广泛应用增加了亚段肺栓塞的诊断比例。这些栓塞的临床意义和预后尚不清楚,抗凝治疗的益处也尚未得到证实。几种先前经过验证的肺栓塞排除诊断策略(基于单排螺旋CT和通气灌注肺扫描)无法检测到大多数此类亚段肺栓塞。然而,这些策略已被证明是安全的,3个月时血栓栓塞事件极少。此外,使用单排螺旋CT和多排螺旋CT的研究之间的比较表明,肺栓塞诊断率增加,接受抗凝治疗的患者比例增加,但3个月随访结果并无改善。亚段肺栓塞似乎比近端肺栓塞的临床影响更小,长期预后更好。在一些孤立性亚段肺栓塞患者中,抗凝相关的出血风险可能超过预防复发性血栓栓塞事件的益处。