Department of Radiation Oncology, UMass Memorial Healthcare, University of Massachusetts Medical School, Worcester, MA, USA.
Semin Radiat Oncol. 2012 Jan;22(1):18-28. doi: 10.1016/j.semradonc.2011.09.004.
In this review article, we address the radiation oncology process improvements in clinical trials and review how these changes improve the quality for the next generation of trials. In recent years, we have progressed from a time of limited data acquisition to the present in which we have real-time influence of clinical trials quality. This enables immediate availability of the important elements, including staging, eligibility, response, and outcome for all trial investigators. Modern informatics platforms are well designed for future adaptive clinical trials. We review what will be needed in the informatics architecture of current and future clinical trials.
在这篇综述文章中,我们探讨了临床试验中放射肿瘤学流程的改进,并回顾了这些变化如何提高下一代试验的质量。近年来,我们已经从数据采集有限的时代发展到了现在,临床试验质量具有实时影响力。这使得所有试验研究者都能立即获得重要元素,包括分期、资格、反应和结果。现代信息学平台非常适合未来的适应性临床试验。我们回顾了当前和未来临床试验的信息学架构所需的内容。