剪切波弥散度可用于测量肝脏脂肪变性。
Shear wave dispersion measures liver steatosis.
机构信息
School of Medicine and Dentistry, University of Rochester, Rochester, NY 14627-0126, USA.
出版信息
Ultrasound Med Biol. 2012 Feb;38(2):175-82. doi: 10.1016/j.ultrasmedbio.2011.10.019. Epub 2011 Dec 16.
Abstract
Crawling waves, which are interfering shear wave patterns, can be generated in liver tissue over a range of frequencies. Some important biomechanical properties of the liver can be determined by imaging the crawling waves using Doppler techniques and analyzing the patterns. We report that the dispersion of shear wave velocity and attenuation, that is, the frequency dependence of these parameters, are strongly correlated with the degree of steatosis in a mouse liver model, ex vivo. The results demonstrate the possibility of assessing liver steatosis using noninvasive imaging methods that are compatible with color Doppler scanners and, furthermore, suggest that liver steatosis can be separated from fibrosis by assessing the dispersion or frequency dependence of shear wave propagations.
摘要
爬行波是一种干扰剪切波的模式，可以在肝脏组织的多个频率范围内产生。通过使用多普勒技术对爬行波成像并分析其模式，可以确定肝脏的一些重要生物力学特性。我们报告称，剪切波速度和衰减的频散，即这些参数的频率依赖性，与小鼠肝模型的脂肪变性程度密切相关，这是在离体状态下观察到的。这些结果表明，使用与彩色多普勒扫描仪兼容的非侵入性成像方法评估肝脂肪变性是可能的，并且进一步表明可以通过评估剪切波传播的频散或频率依赖性来区分肝脂肪变性和纤维化。
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