• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Pathogenesis of non-alcoholic fatty liver disease.

作者信息

Dowman J K, Tomlinson J W, Newsome P N

机构信息

Centre for Liver Research, Institute of Biomedical Research, University of Birmingham, B15 2TT, Birmingham, UK.

出版信息

QJM. 2010 Feb;103(2):71-83. doi: 10.1093/qjmed/hcp158. Epub 2009 Nov 13.

DOI:10.1093/qjmed/hcp158
PMID:19914930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2810391/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/062a/2810391/bae76f26d14a/hcp158f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/062a/2810391/b739a3124326/hcp158f1a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/062a/2810391/a5e550dc5b1b/hcp158f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/062a/2810391/bae76f26d14a/hcp158f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/062a/2810391/b739a3124326/hcp158f1a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/062a/2810391/a5e550dc5b1b/hcp158f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/062a/2810391/bae76f26d14a/hcp158f3.jpg

相似文献

1
Pathogenesis of non-alcoholic fatty liver disease.非酒精性脂肪性肝病的发病机制。
QJM. 2010 Feb;103(2):71-83. doi: 10.1093/qjmed/hcp158. Epub 2009 Nov 13.
2
New concepts in the pathogenesis of alcoholic liver disease.酒精性肝病发病机制的新概念。
Expert Rev Gastroenterol Hepatol. 2008 Dec;2(6):749-59. doi: 10.1586/17474124.2.6.749.
3
[Fatty liver and its clinical management in obese adolescents].[肥胖青少年的脂肪肝及其临床管理]
Endocrinol Nutr. 2011 Jan;58(1):32-7. doi: 10.1016/j.endonu.2010.10.005. Epub 2011 Jan 7.
4
Non-alcoholic steatohepatitis and metabolic syndrome.非酒精性脂肪性肝炎与代谢综合征
Curr Opin Clin Nutr Metab Care. 2006 Sep;9(5):637-42. doi: 10.1097/01.mco.0000241677.40170.17.
5
Non-alcoholic steatohepatitis: pathogenesis and novel therapeutic approaches.非酒精性脂肪性肝炎:发病机制与新型治疗方法。
J Gastroenterol Hepatol. 2013 Aug;28 Suppl 1:68-76. doi: 10.1111/jgh.12212.
6
Review article: the pathogenesis of fibrosis in non-alcoholic steatohepatitis.综述文章:非酒精性脂肪性肝炎中纤维化的发病机制
Aliment Pharmacol Ther. 2005 Nov;22 Suppl 2:44-7. doi: 10.1111/j.1365-2036.2005.02595.x.
7
Non-alcoholic fatty liver disease.非酒精性脂肪性肝病。
J Diabetes. 2012 Sep;4(3):266-80. doi: 10.1111/j.1753-0407.2012.00204.x.
8
Novel therapeutic targets for steatohepatitis.非酒精性脂肪性肝炎的新型治疗靶点。
Clin Res Hepatol Gastroenterol. 2015 Sep;39 Suppl 1:S46-50. doi: 10.1016/j.clinre.2015.05.012. Epub 2015 Jul 6.
9
Pathogenesis of non-alcoholic steatohepatitis: human data.非酒精性脂肪性肝炎的发病机制:人类数据。
Clin Liver Dis. 2007 Feb;11(1):75-104, ix. doi: 10.1016/j.cld.2007.02.011.
10
Non-alcoholic fatty liver disease: further expression of the metabolic syndrome.非酒精性脂肪性肝病:代谢综合征的进一步表现。
J Gastroenterol Hepatol. 2007 Mar;22(3):293-303. doi: 10.1111/j.1440-1746.2007.04824.x.

引用本文的文献

1
Targeting cAMP signaling and phosphodiesterase 4 for liver disease treatment.以环磷酸腺苷(cAMP)信号传导和磷酸二酯酶4为靶点治疗肝脏疾病。
Med Chem Res. 2024 Aug;33(8):1339-1353. doi: 10.1007/s00044-024-03267-3. Epub 2024 Jun 26.
2
Dynamic changes in macrophage populations and resulting alterations in Prostaglandin E sensitivity in mice with diet-induced MASH.饮食诱导的小鼠代谢相关脂肪性肝病中巨噬细胞群体的动态变化及由此导致的前列腺素E敏感性改变。
Cell Commun Signal. 2025 May 16;23(1):227. doi: 10.1186/s12964-025-02222-y.
3
The Role of Short-Chain Fatty Acids in Metabolic Dysfunction-Associated Steatotic Liver Disease and Other Metabolic Diseases.

本文引用的文献

1
A pilot study using simvastatin in the treatment of nonalcoholic steatohepatitis: A randomized placebo-controlled trial.一项使用辛伐他汀治疗非酒精性脂肪性肝炎的初步研究:一项随机安慰剂对照试验。
J Clin Gastroenterol. 2009 Nov-Dec;43(10):990-4. doi: 10.1097/MCG.0b013e31819c392e.
2
Serum adipokine levels predictive of liver injury in non-alcoholic fatty liver disease.预测非酒精性脂肪性肝病肝损伤的血清脂肪因子水平
Liver Int. 2009 Oct;29(9):1431-8. doi: 10.1111/j.1478-3231.2009.02022.x. Epub 2009 Apr 24.
3
Hepatic progenitor cell-mediated regeneration and fibrosis: chicken or egg?
短链脂肪酸在代谢功能障碍相关脂肪性肝病及其他代谢性疾病中的作用
Biomolecules. 2025 Mar 22;15(4):469. doi: 10.3390/biom15040469.
4
Substrates (Acyl-CoA and Diacylglycerol) Entry and Products (CoA and Triacylglycerol) Egress Pathways in DGAT1.二酰甘油酰基转移酶1(DGAT1)中的底物(酰基辅酶A和二酰甘油)进入途径及产物(辅酶A和三酰甘油)流出途径
J Comput Chem. 2025 Apr 30;46(11):e70108. doi: 10.1002/jcc.70108.
5
Placenta nanoparticle treatment in guinea pigs mitigates FGR-associated fetal sex-dependent effects on liver metabolism-related signaling pathways.豚鼠胎盘纳米颗粒治疗可减轻与胎儿生长受限相关的、对肝脏代谢相关信号通路的胎儿性别依赖性影响。
Am J Physiol Endocrinol Metab. 2025 Mar 1;328(3):E395-E409. doi: 10.1152/ajpendo.00440.2024. Epub 2025 Feb 5.
6
In Vitro Evaluation of Probiotic Activities and Anti-Obesity Effects of EF-1 in Mice Fed a High-Fat Diet.高脂饮食喂养小鼠中益生菌EF-1活性及抗肥胖作用的体外评价
Foods. 2024 Dec 18;13(24):4095. doi: 10.3390/foods13244095.
7
Sex Hormone: A Potential Target at Treating Female Metabolic Dysfunction-Associated Steatotic Liver Disease?性激素:治疗女性代谢功能障碍相关脂肪性肝病的潜在靶点?
J Clin Exp Hepatol. 2025 Mar-Apr;15(2):102459. doi: 10.1016/j.jceh.2024.102459. Epub 2024 Nov 19.
8
Quercetin: A Promising Candidate for the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).槲皮素:代谢功能障碍相关脂肪性肝病(MASLD)管理的有前途的候选药物。
Molecules. 2024 Nov 6;29(22):5245. doi: 10.3390/molecules29225245.
9
Prevalence of metabolic dysfunction-associated steatotic liver disease in people living with HIV and on antiretroviral treatment: A systematic review and meta-analysis protocol.接受抗逆转录病毒治疗的HIV感染者中代谢功能障碍相关脂肪性肝病的患病率:一项系统评价和荟萃分析方案
Health Sci Rep. 2024 Oct 28;7(11):e70071. doi: 10.1002/hsr2.70071. eCollection 2024 Nov.
10
Understanding Macrophage Complexity in Metabolic Dysfunction-Associated Steatotic Liver Disease: Transitioning from the M1/M2 Paradigm to Spatial Dynamics.了解代谢功能障碍相关脂肪性肝病中的巨噬细胞复杂性:从M1/M2范式向空间动态转变
Livers. 2024 Sep;4(3):455-478. doi: 10.3390/livers4030033. Epub 2024 Sep 13.
肝祖细胞介导的再生与纤维化:先有鸡还是先有蛋?
Hepatology. 2009 May;49(5):1424-6. doi: 10.1002/hep.22893.
4
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice.GRP78表达可抑制胰岛素和内质网应激诱导的SREBP-1c激活,并减轻小鼠肝脏脂肪变性。
J Clin Invest. 2009 May;119(5):1201-15. doi: 10.1172/JCI37007. Epub 2009 Apr 13.
5
Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats.益生菌可减轻高脂饮食诱导的幼鼠肝脏炎症反应。
J Nutr. 2009 May;139(5):905-11. doi: 10.3945/jn.108.101808. Epub 2009 Mar 25.
6
Could inflammatory markers help diagnose nonalcoholic steatohepatitis?炎症标志物能否有助于诊断非酒精性脂肪性肝炎?
Eur J Gastroenterol Hepatol. 2009 May;21(5):504-11. doi: 10.1097/MEG.0b013e3283229b40.
7
Overexpression of liver-specific cytochrome P4502E1 impairs hepatic insulin signaling in a transgenic mouse model of nonalcoholic fatty liver disease.过表达肝特异性细胞色素 P4502E1 可损害非酒精性脂肪性肝病转基因小鼠模型的肝胰岛素信号。
Eur J Gastroenterol Hepatol. 2009 Sep;21(9):973-83. doi: 10.1097/MEG.0b013e328328f461.
8
Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis.血管紧张素II激活RelA在丝氨酸536处的IκB激酶磷酸化,以促进肌成纤维细胞存活和肝纤维化。
Gastroenterology. 2009 Jun;136(7):2334-2344.e1. doi: 10.1053/j.gastro.2009.02.081. Epub 2009 Mar 18.
9
Association between angiotensin II type 1 receptor polymorphisms and the occurrence of nonalcoholic fatty liver disease.血管紧张素II 1型受体基因多态性与非酒精性脂肪性肝病发生之间的关联。
Liver Int. 2009 Aug;29(7):1078-85. doi: 10.1111/j.1478-3231.2009.01988.x. Epub 2009 Mar 3.
10
Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury.在CDE诱导的慢性肝损伤小鼠模型中肝祖细胞扩增与细胞外基质沉积之间的关系
Hepatology. 2009 May;49(5):1625-35. doi: 10.1002/hep.22820.