Serra-Guillén C, Nagore E, Guillén C
Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España.
Actas Dermosifiliogr. 2012 Jul-Aug;103(6):488-501. doi: 10.1016/j.ad.2011.10.003. Epub 2011 Dec 16.
Photodynamic therapy and imiquimod are highly regarded treatments dermatologists frequently prescribe for actinic keratoses, basal cell carcinoma, and Bowen disease. The scarcity of evidence from comparative trials prevents us from drawing well-founded conclusions about the efficacy, tolerance, and adverse effects of these therapeutic options or to recommend one over the other in any particular type of lesion or patient. On the other hand, in certain conditions (eg, actinic chelitis, immunosuppression, and basal cell carcinoma affecting the eyelids), there is evidence to support the use of photodynamic therapy or imiquimod even though they might initially seem contraindicated. We critically review and compare the use of these 2 treatments in order to suggest which is more appropriate in specific cases.
光动力疗法和咪喹莫特是皮肤科医生常用于治疗光化性角化病、基底细胞癌和鲍温病的备受推崇的疗法。比较试验的证据稀缺，这使我们无法就这些治疗方案的疗效、耐受性和不良反应得出有充分依据的结论，也无法在任何特定类型的病变或患者中推荐其中一种优于另一种。另一方面，在某些情况下（如光化性唇炎、免疫抑制以及累及眼睑的基底细胞癌），尽管光动力疗法或咪喹莫特最初看似禁忌，但有证据支持使用它们。我们对这两种治疗方法的应用进行了批判性审查和比较，以表明在特定情况下哪种方法更合适。
