Wanski Z J, Robinson A G, Jannetta P J
Metabolism. 1979 Jun;28(6):624-8. doi: 10.1016/0026-0495(79)90014-3.
Acromegaly is caused by hypersecretion of growth hormone by the pituitary. There is some debate as to whether the primary etiology of the disease is abnormal hypothalamic stimulation of the pituitary or a primary pituitary tumor. This paper presents a case of acromegaly in which growth hormone dynamics in response to stimulation and suppression tests were abnormal. After transsphenoidal adenomectomy of a small tumor, growth hormone levels returned to normal and suppression and stimulation test results reverted to normal within 1 wk postoperatively and remained normal for 2 yr. The findings suggest that the acromegaly in this case was due to a primary pituitary dysfunction. Microsurgical removal of growth-hormone-secreting tumors provides a unique opportunity to study the etiology of acromegaly.
肢端肥大症是由垂体生长激素分泌过多引起的。关于该疾病的主要病因是下丘脑对垂体的异常刺激还是原发性垂体肿瘤，存在一些争议。本文介绍了一例肢端肥大症病例，其生长激素对刺激和抑制试验的反应动力学异常。在对一个小肿瘤进行经蝶窦腺瘤切除术后，生长激素水平恢复正常，抑制和刺激试验结果在术后1周内恢复正常，并在2年内保持正常。这些发现表明，该病例中的肢端肥大症是由原发性垂体功能障碍引起的。显微手术切除分泌生长激素的肿瘤为研究肢端肥大症的病因提供了独特的机会。
