Department of Oral Medicine and Oral Pathology, University of Thessaloniki, Thessaloniki, Greece.
Med Princ Pract. 2012;21(3):288-91. doi: 10.1159/000334587. Epub 2011 Dec 17.
To report a case of coexisting irritation fibroma and myofibroma in oral mucosa.
One case with two painless, nodular masses, adjacent to each other in the buccal mucosa, was clinically examined with a provisional diagnosis of irritation fibroma, salivary gland tumors, neurofibroma and schwannoma. Histological examination of the smaller swelling showed features of irritation fibroma, while the features of the other mass were compatible with myofibroma or leiomyoma. Additional immunohistochemical examination established the diagnosis of myofibroma.
This was a case of a myofibroma that was clinically similar to an adjacent irritation fibroma, which highlights the possibility of misdiagnosis of a myofibroblastic tumor and underlines the importance of histologic examination together with immunohistochemical and/or histochemical analysis if necessary to establish the accurate diagnosis.
报告一例口腔黏膜共存的刺激纤维瘤和肌纤维瘤。
一例患者颊黏膜上有两个相邻的无痛性结节状肿块,临床初步诊断为刺激纤维瘤、唾液腺肿瘤、神经纤维瘤和雪旺细胞瘤。较小肿块的组织学检查显示为刺激纤维瘤的特征,而另一个肿块的特征与肌纤维瘤或平滑肌瘤一致。进一步的免疫组织化学检查确立了肌纤维瘤的诊断。
这是一例临床上类似于相邻刺激纤维瘤的肌纤维瘤,提示肌纤维母细胞瘤的误诊可能性,并强调了如果必要,通过组织学检查以及免疫组织化学和/或组织化学分析来确定准确诊断的重要性。