男性性别决定：分子机制的研究进展。
Male sex determination: insights into molecular mechanisms.
机构信息
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
出版信息
Asian J Androl. 2012 Jan;14(1):164-71. doi: 10.1038/aja.2011.169. Epub 2011 Dec 19.
Abstract
Disorders of sex development often arise from anomalies in the molecular or cellular networks that guide the differentiation of the embryonic gonad into either a testis or an ovary, two functionally distinct organs. The activation of the Y-linked gene Sry (sex-determining region Y) and its downstream target Sox9 (Sry box-containing gene 9) triggers testis differentiation by stimulating the differentiation of Sertoli cells, which then direct testis morphogenesis. Once engaged, a genetic pathway promotes the testis development while actively suppressing genes involved in ovarian development. This review focuses on the events of testis determination and the struggle to maintain male fate in the face of antagonistic pressure from the underlying female programme.
摘要
性发育障碍通常源于指导胚胎性腺分化为睾丸或卵巢的分子或细胞网络的异常，睾丸和卵巢是两个具有不同功能的器官。Y 染色体上的基因 Sry（性别决定区 Y）及其下游靶基因 Sox9（Sry 盒基因 9）的激活通过刺激支持细胞的分化来触发睾丸分化，然后指导睾丸形态发生。一旦启动，一条遗传途径就会促进睾丸发育，同时积极抑制与卵巢发育相关的基因。本综述重点介绍睾丸决定的事件，以及在面临潜在的女性程序拮抗压力时，努力维持雄性命运的过程。
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