鼓室内注射类固醇用于Vogt-小柳-原田综合征的听力挽救治疗。

Intratympanic steroid use for hearing salvage in Vogt-Koyanagi-Harada syndrome.

作者信息

Pelosi Stanley, Chandrasekhar Sujana S

机构信息

Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, 7209 Medical Center East, South Tower, 1215 21st Ave. South, Nashville, TN 37232, USA.

出版信息

Ear Nose Throat J. 2011 Dec;90(12):574-7. doi: 10.1177/014556131109001206.

DOI:10.1177/014556131109001206

PMID:22180111

Abstract

We discuss the rare case of a 68-year-old woman with Vogt-Koyanagi-Harada (VKH) syndrome and sensorineural hearing loss (SNHL) who was successfully treated with intratympanic corticosteroid injections. The patient had presented with bilaterally asymmetric (i.e., moderate and moderate to severe) SNHL, tinnitus, vertigo, and vitiligo. She received two intratympanic injections in her worse-hearing ear over the course of 1 month. Subsequent audiometry showed an immediate 5- to 10-dB improvement in her hearing across multiple frequencies, as well as a long-term improvement to near-normal thresholds. The hearing thresholds in her untreated ear remained stable. To the best of our knowledge, this is the first report of a patient with VKH syndrome who was successfully treated with intratympanic steroid application.

摘要

我们讨论了一例罕见病例，一名68岁患有伏格特-小柳-原田（VKH）综合征和感音神经性听力损失（SNHL）的女性患者，通过鼓室内注射皮质类固醇成功治愈。该患者表现为双侧不对称（即中度和中度至重度）SNHL、耳鸣、眩晕和白癜风。在1个月的时间里，她在听力较差的耳朵接受了两次鼓室内注射。随后的听力测定显示，多个频率的听力立即提高了5至10分贝，并且长期改善至接近正常阈值。她未治疗耳朵的听力阈值保持稳定。据我们所知，这是首例用鼓室内应用类固醇成功治疗的VKH综合征患者的报告。