Savage Natasha M, Crosby John H, Reid-Nicholson Michelle D
Department of Pathology, Medical College of Georgia, Augusta, Georgia, USA.
Diagn Cytopathol. 2012 Jan;40(1):1-6. doi: 10.1002/dc.21478. Epub 2010 Nov 15.
Choroid plexus carcinoma is a rare tumor of the choroid plexus that shows frank cytologic features of malignancy including frequent mitoses, increased cellularity, nuclear pleomorphism, loss of papillary architecture, and necrosis. It occurs predominantly in the pediatric population and is associated with a poor prognosis. We report the cerebrospinal fluid and intraoperative squash preparation cytologic findings of a case of choroid plexus carcinoma arising in the lateral ventricle of a 16-year-old girl who developed tumor recurrence in cerebrospinal fluid 6 years after initial resection. To the best of our knowledge, there are only a few reports in the English literature describing the cytologic features of choroid plexus carcinoma. Relevant differentials and the usefulness of ancillary studies in diagnosis are also discussed.
脉络丛癌是一种罕见的脉络丛肿瘤，具有明显的恶性细胞学特征，包括频繁的有丝分裂、细胞增多、核多形性、乳头状结构丧失和坏死。它主要发生在儿童人群中，预后较差。我们报告了一例16岁女孩侧脑室脉络丛癌的脑脊液和术中压片制备细胞学检查结果，该女孩在初次切除6年后脑脊液中出现肿瘤复发。据我们所知，英文文献中仅有少数报道描述脉络丛癌的细胞学特征。本文还讨论了相关鉴别诊断及辅助检查在诊断中的作用。
