Department of Pathology, University of Colorado Denver, Aurora, CO 80045, USA.
Am J Clin Pathol. 2012 Jan;137(1):150-5. doi: 10.1309/AJCP6LW4SYBTISOW.
Although rapid prescreening (RPS) has been shown to be an effective quality control procedure for detecting false-negative conventional Papanicolaou (Pap) tests, RPS has not been widely implemented in the United States. In our laboratory, cytotechnologists performed RPS in 3,567 liquid-based Pap tests: 1,911 SurePath (BD Diagnostics-TriPath, Burlington, NC) preparations that were manually screened and 1,656 ThinPrep Pap tests (Hologic, Bedford, MA) that were imaged using the ThinPrep Imaging System (Hologic). We compared the sensitivity of RPS, 10% rescreening (R-10%), and routine screening (RS). In contrast with previously published findings, we found that RS + RPS did not improve screening sensitivity compared with RS + R-10%. These results support the following hypotheses: (1) Higher baseline RS sensitivity as a result of Pap test diagnoses standardization implemented for quality improvement purposes decreases the performance impact of RPS. (2) R-10% and RPS quality assurance methods detect diagnostic failures caused by different types of cognitive errors.
虽然快速预筛查（RPS）已被证明是一种有效的质量控制程序，可用于检测假阴性传统巴氏涂片（Pap）检测，但它并未在美国得到广泛实施。在我们的实验室中，细胞技术人员对 3567 例液基巴氏涂片检测进行了 RPS：1911 例SurePath（BD Diagnostics-TriPath，北卡罗来纳州伯灵顿）制剂采用手动筛查，1656 例 ThinPrep Pap 检测采用 ThinPrep 成像系统（Hologic，马萨诸塞州贝德福德）进行成像。我们比较了 RPS、10%复查（R-10%）和常规筛查（RS）的敏感性。与之前发表的研究结果不同，我们发现与 RS + R-10%相比，RS + RPS 并未提高筛查敏感性。这些结果支持以下假设：（1）为提高质量而实施的巴氏涂片检测诊断标准化导致的基线 RS 敏感性较高，降低了 RPS 的性能影响。（2）R-10%和 RPS 质量保证方法检测到由不同类型认知错误引起的诊断失败。
