School of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol BS8 1TU, UK.
Nicotine Tob Res. 2012 Aug;14(8):993-7. doi: 10.1093/ntr/ntr246. Epub 2011 Dec 17.
The α4β2 nicotinic receptor is of central importance in tobacco dependence, while the homomeric α7 receptor may also play a role. In this candidate gene study, we examine the association between 8 single nucleotide polymorphisms (SNPs) in genes coding for nicotinic acetylcholine receptor subunits α4 (rs1044396, rs2273504, rs2236196, and rs2273502), α7 (rs2133965 and rs4779969), and β2 (rs2072660 and rs2072661) and smoking abstinence in a cohort of quitters enrolled in a clinical trial of behavioral support.
Data were obtained from the "Patch in Practice" study, involving 925 smokers in the United Kingdom. All participants were given an 8-week course of 15 mg of transdermal nicotine replacement therapy and blood was taken for genotyping.
Logistic regression analyses assessed the association between each selected SNP and smoking abstinence at 4, 12, 26, and 52 weeks. There were no statistically significant associations with smoking cessation success or nicotine intake assessed by plasma cotinine levels. However, rs2273502 was associated with a consistent (though nonsignificant) increase in the odds of abstinence.
There was no compelling evidence that these SNPs were associated with a reduced or higher chance of abstinence. However, rs2273502 may be worth investigating in future studies.
α4β2 型烟碱型乙酰胆碱受体在烟草依赖中具有重要作用，而同源 α7 受体也可能发挥作用。在这项候选基因研究中，我们研究了编码烟碱型乙酰胆碱受体亚基α4（rs1044396、rs2273504、rs2236196 和 rs2273502）、α7（rs2133965 和 rs4779969）和β2（rs2072660 和 rs2072661）的 8 个单核苷酸多态性（SNP）与戒烟者队列中戒烟的相关性，这些患者参与了一项行为支持临床试验。
数据来自“实践中的贴片”研究，涉及英国的 925 名吸烟者。所有参与者都接受了为期 8 周、剂量为 15 毫克的经皮尼古丁替代疗法，并进行了基因分型。
逻辑回归分析评估了每个选定 SNP 与 4、12、26 和 52 周时的吸烟戒断成功之间的关联。与戒烟成功或通过血浆可替宁水平评估的尼古丁摄入量没有统计学意义的关联。然而，rs2273502 与戒烟的几率持续（尽管无统计学意义）增加相关。
没有令人信服的证据表明这些 SNP 与降低或增加戒烟的机会有关。然而，rs2273502 可能值得在未来的研究中进行调查。
