National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborative Center for Malaria, Schistosomiasis and Filariasis, Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, People's Republic of China.
PLoS Negl Trop Dis. 2011 Dec;5(12):e1377. doi: 10.1371/journal.pntd.0001377. Epub 2011 Dec 13.
Clonorchiasis is among the most neglected tropical diseases. It is caused by ingesting raw or undercooked fish or shrimp containing the larval of Clonorchis sinensis and mainly endemic in Southeast Asia including China, Korea and Vietnam. The global estimations for population at risk and infected are 601 million and 35 million, respectively. However, it is still not listed among the Global Burden of Disease (GBD) and no disability weight is available for it. Disability weight reflects the average degree of loss of life value due to certain chronic disease condition and ranges between 0 (complete health) and 1 (death). It is crucial parameter for calculating the morbidity part of any disease burden in terms of disability-adjusted life years (DALYs).
METHODOLOGY/PRINCIPAL FINDINGS: According to the probability and disability weight of single sequelae caused by C. sinensis infection, the overall disability weight could be captured through Monte Carlo simulation. The probability of single sequelae was gained from one community investigation, while the corresponding disability weight was searched from the literatures in evidence-based approach. The overall disability weights of the male and female were 0.101 and 0.050, respectively. The overall disability weights of the age group of 5-14, 15-29, 30-44, 45-59 and 60+ were 0.022, 0.052, 0.072, 0.094 and 0.118, respectively. There was some evidence showing that the disability weight and geometric mean of eggs per gram of feces (GMEPG) fitted a logarithmic equation.
CONCLUSION/SIGNIFICANCE: The overall disability weights of C. sinensis infection are differential in different sex and age groups. The disability weight captured here may be referred for estimating the disease burden of C. sinensis infection.
华支睾吸虫病是最被忽视的热带病之一。它是由食用含有华支睾吸虫幼虫的生的或未煮熟的鱼或虾引起的，主要流行于包括中国、韩国和越南在内的东南亚地区。全球有 6 亿人处于感染风险之中，感染者约为 3500 万。然而，它仍未被列入全球疾病负担（GBD），也没有为其提供残疾权重。残疾权重反映了由于某些慢性疾病状况导致的平均生命价值丧失程度，范围在 0（完全健康）到 1（死亡）之间。它是用残疾调整生命年来计算任何疾病负担的发病率部分的关键参数。
方法/主要发现：根据华支睾吸虫感染单一后遗症的概率和残疾权重，可通过蒙特卡罗模拟来获取整体残疾权重。单种后遗症的概率是从一项社区调查中获得的，而相应的残疾权重是通过循证方法从文献中搜索到的。男性和女性的总残疾权重分别为 0.101 和 0.050。5-14 岁、15-29 岁、30-44 岁、45-59 岁和 60 岁以上的人群的总残疾权重分别为 0.022、0.052、0.072、0.094 和 0.118。有一些证据表明，残疾权重和粪便每克卵的几何均数（GMEPG）拟合对数方程。
结论/意义：华支睾吸虫感染的总残疾权重在不同性别和年龄组之间存在差异。这里获取的残疾权重可用于估计华支睾吸虫感染的疾病负担。
