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微创脊柱外科 (MASS) 作为门诊手术用于治疗转移性脊柱肿瘤的减压和稳定,随后进行脊柱立体定向体放射治疗 (SBRT):技术的首次报告和初步结果。

Minimal access spine surgery (MASS) for decompression and stabilization performed as an out-patient procedure for metastatic spinal tumours followed by spine stereotactic body radiotherapy (SBRT): first report of technique and preliminary outcomes.

机构信息

Division of Neurosurgery and Krembil Neuroscience-Spinal Program, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.

出版信息

Technol Cancer Res Treat. 2012 Feb;11(1):15-25. doi: 10.7785/tcrt.2012.500230.

Abstract

We report a novel approach in the treatment of spinal metastases with epidural disease and mechanical instability using a combined minimal access spine surgery (MASS) technique followed by spine stereotactic body radiotherapy (SBRT). This study was performed as a retrospective review of the first ten consecutive patients treated with this combined approach. The MASS technique was based on a tubular retraction system to gain access for decompression and mechanical stabilization achieved using methyl-methacrylate (MMA) applied under direct visualization. SBRT consisted of one to five image-guided high dose per fraction treatments. Eight patients were symptomatic at baseline. Pain, disability, and quality of life (QOL) were prospectively determined using the visual analogue score (VAS), Oswestry Disability Index (ODI), and Short-Form-36 version 2, respectively. The median follow-up was 13 months (range, 3-18). MASS successfully decompressed each patient. The median blood loss was 335 ml. Following MASS, the median time to SBRT treatment planning was 6.5 days and subsequent median time to treatment was 7 days. Local control was observed in 7 of the 10 patients. Improvements in VAS, ODI and QOL were observed post-SBRT. We report preliminary efficacy for our MASS-SBRT combined approach for patients with spinal metastases, mechanical pain and epidural disease.

摘要

我们报告了一种使用微创脊柱外科(MASS)技术联合脊柱立体定向体放射治疗(SBRT)治疗伴硬膜外疾病和机械不稳定的脊柱转移瘤的新方法。这项研究是对采用这种联合方法治疗的前十例连续患者进行的回顾性研究。MASS 技术基于管状牵开系统,以获得减压和机械稳定的通道,使用甲基丙烯酸甲酯(MMA)在直接可视化下应用。SBRT 由一到五次图像引导的高剂量分次治疗组成。8 名患者在基线时出现症状。疼痛、残疾和生活质量(QOL)分别采用视觉模拟评分(VAS)、Oswestry 残疾指数(ODI)和简短形式 36 版 2 进行前瞻性评估。中位随访时间为 13 个月(范围 3-18 个月)。MASS 成功地为每位患者进行了减压。中位出血量为 335ml。MASS 后,SBRT 治疗计划的中位时间为 6.5 天,随后的中位治疗时间为 7 天。10 例患者中有 7 例观察到局部控制。SBRT 后 VAS、ODI 和 QOL 均有改善。我们报告了 MASS-SBRT 联合方法治疗伴机械性疼痛和硬膜外疾病的脊柱转移瘤患者的初步疗效。

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