Nakayama Hiroki, Okamoto Hiroyuki, Okuma Kae, Nagao Ayaka, Tsunoda Yuki, Nakamura Satoshi, Chiba Takahito, Nakaichi Tetsu, Yonemura Miki, Oshika Riki, Kobayashi Yuta, Kishida Hironori, Nakamura Shoki, Nishitani Masato, Nishina Shuka, Sakamoto Takumi, Endo Hana, Kuwahara Junichi, Shuto Yasunori, Ueda Masataka, Kaneda Tomoya, Igaki Hiroshi
Radiation Safety and Quality Assurance Division, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.
Department of Radiation Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.
Adv Radiat Oncol. 2025 Jun 28;10(9):101843. doi: 10.1016/j.adro.2025.101843. eCollection 2025 Sep.
The rise in radiation therapy challenges facing the management of pain and neurologic symptoms from vertebral metastasis has paralleled advances in cancer treatment and patient prognosis. Surgical options include decompression to alleviate spinal cord compression symptoms, with consideration for spinal stability through fixation using titanium alloy implants. Previous studies comparing radiation alone with postoperative irradiation following decompression surgery showed superior functional outcomes. Stereotactic body radiation therapy (SBRT), which concentrates radiation on the tumor while sparing surrounding organs, has clinical advantages when combined with surgery. However, the accurate delineation of targets and organs, particularly the spinal cord of a patient with metallic implants, is difficult with computed tomography and magnetic resonance (MR) images because of metal artifacts and registration errors. The low-field MR-guided radiation therapy (the low-field MRgRT) system offers advantages in target delineation with metal artifact suppression because of its associated low-magnetic field and no need for registration between a computed tomography image and an MR image for the delineation of targets and organs because the low-field MRgRT system uses the MR image acquired by itself as the primary image. The advantages make the low-field MRgRT suitable for spine SBRT, especially for patients with metallic implants. Here, we present a case of successful postoperative spine SBRT using the low-field MRgRT, ensuring the identification of the spinal cord, and safe and accurate treatment in a patient with metallic implants. The conclusion highlights the low-field MRgRT as a viable option for postoperative spine SBRT, which is particularly beneficial for patients with metallic implants, ensuring treatment safety and accuracy.
在癌症治疗和患者预后取得进展的同时,椎体转移所致疼痛和神经症状管理面临的放射治疗挑战也日益增加。手术选择包括减压以缓解脊髓压迫症状,并考虑通过使用钛合金植入物进行固定来维持脊柱稳定性。以往比较单纯放疗与减压手术后放疗的研究显示,术后放疗的功能预后更佳。立体定向体部放射治疗(SBRT)可将辐射集中于肿瘤,同时保护周围器官,与手术联合应用时具有临床优势。然而,由于金属伪影和配准误差,利用计算机断层扫描(CT)和磁共振(MR)图像精确勾画靶区和器官,尤其是有金属植入物患者的脊髓,存在困难。低场MR引导放射治疗(低场MRgRT)系统具有低磁场的特点,能抑制金属伪影,在靶区勾画方面具有优势,且在勾画靶区和器官时无需在CT图像和MR图像之间进行配准,因为低场MRgRT系统将自身采集的MR图像作为主要图像。这些优势使得低场MRgRT适用于脊柱SBRT,尤其是有金属植入物的患者。在此,我们报告一例使用低场MRgRT成功进行术后脊柱SBRT的病例,该病例确保了脊髓的识别,并对有金属植入物的患者进行了安全、准确的治疗。结论强调低场MRgRT是术后脊柱SBRT的一个可行选择,对有金属植入物的患者尤其有益,可确保治疗的安全性和准确性。