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去氢表雄酮衍生物的体外合成及其对 ES-2、A549 和 HepG2 细胞的抗肿瘤活性。

Synthesis and antitumor activity of dehydroepiandrosterone derivatives on Es-2, A549, and HepG2 cells in vitro.

机构信息

Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, Yanbian University College of Pharmacy, Yanji 133002, China.

出版信息

Chem Biol Drug Des. 2012 Apr;79(4):523-9. doi: 10.1111/j.1747-0285.2011.01311.x. Epub 2012 Jan 30.

DOI:10.1111/j.1747-0285.2011.01311.x
PMID:22181987
Abstract

A series of dehydroepiandrosterone derivatives containing an acid ester was synthesized and evaluated for their antitumor activity on ES-2, A549, and HepG2 cells by the MTT assay. Most compounds showed antitumor activity, while compounds 1c, 2i, and 2o exhibited more potential inhibitory effects compared with dehydroepiandrosterone on ES-2 cells, A549 cells, and HepG2 cells, respectively.

摘要

合成了一系列含有酸酯的脱氢表雄酮衍生物，并通过 MTT 法评估了它们对 ES-2、A549 和 HepG2 细胞的抗肿瘤活性。大多数化合物表现出抗肿瘤活性，而化合物 1c、2i 和 2o 对 ES-2 细胞、A549 细胞和 HepG2 细胞的抑制作用均强于脱氢表雄酮。

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