Sinhgad College of Pharmacy, Post-Graduate Research Department, Vadgaon (Bk), Pune, Maharashtra, India.
J Psychopharmacol. 2012 Feb;26(2):315-23. doi: 10.1177/0269881111431749. Epub 2011 Dec 18.
Nicotinic acetylcholine receptors mediate some of the rewarding and motivational effects of ethanol, including relapses. Relapses are common in drug addicts during abstinence when exposure to any stressor ensues. However, the role of nicotinic acetylcholine receptors in the ethanol- and stress-induced reinstatement of ethanol-induced conditioned place preference has not yet been explored. Therefore, the present study investigated the influence of mecamylamine, a nicotinic acetylcholine receptors antagonist on acquisition, expression, and reinstatement of ethanol-induced conditioned place preference in adult male Swiss mice. The results revealed that mecamylamine (0.1-10 µg/mouse, intracerebroventricularly) dose dependently prevented the development, expression, and reinstatement of ethanol-induced conditioned place preference. Further, acute treatment with mecamylamine blocked the restraint stress and forced swim stress-induced reinstatement of ethanol-induced conditioned place preference. All of these treatments had no influence on the locomotor activity. Therefore, it is concluded that mecamylamine blocks the acquisition, expression and reinstatement of conditioned reinforcing effects of ethanol without per se reinforcing or aversive influence. This ability of mecamylamine might be a potential advantage in the treatment of alcoholism.
烟碱型乙酰胆碱受体介导了乙醇的一些奖赏和动机效应，包括复发。在药物成瘾者戒断期间，暴露于任何应激源都会导致复发。然而，烟碱型乙酰胆碱受体在乙醇和应激诱导的乙醇诱导的条件性位置偏好复燃中的作用尚未得到探索。因此，本研究探讨了烟碱型乙酰胆碱受体拮抗剂美加明（mecamylamine）对成年雄性瑞士小鼠乙醇诱导的条件性位置偏好的获得、表达和复燃的影响。结果表明，美加明（0.1-10μg/只，侧脑室注射）剂量依赖性地预防了乙醇诱导的条件性位置偏好的发展、表达和复燃。此外，急性美加明处理阻断了束缚应激和强迫游泳应激诱导的乙醇诱导的条件性位置偏好复燃。所有这些处理对运动活动均没有影响。因此，结论是美加明阻断了乙醇的获得、表达和条件强化效应的复燃，而没有自身强化或厌恶影响。美加明的这种能力可能是治疗酒精中毒的一个潜在优势。
