黑色素瘤抗原A3（MAGE-A3）表达是弥漫性大B细胞淋巴瘤的不良预后因素。
MAGE-A3 expression is an adverse prognostic factor in diffuse large B-cell lymphoma.
作者信息
Olarte Irma, Martinez Adolfo, Ramos-Peñafiel Christian, Castellanos-Sinco Humberto, Zamora Jorge, Collazo-Jaloma Juan, Gutiérrez Mario, Gutiérrez-Kobeh Laila, Chavez-Olmos Pedro, Manzanilla Hugo, Garrido-Guerrero Efraín, Ordoñez-Razo Rosa M, Miranda Enrique I
机构信息
Laboratorio de Biología Molecular, Servicio de Hematología, Hospital General de México, México D.F., México.
出版信息
Hematology. 2011 Nov;16(6):368-72. doi: 10.1179/102453311X13085644680384.
This study evaluates the prognostic value of MAGE-A3 expression in 28 diffuse large B-cell lymphoma (DLBCL) patients. A significant association was observed between MAGE-A3 expressions, assessed by quantitative real-time RT-polymerase chain reaction (PCR), with advanced stages of disease (P < 0.05). Elevated serum lactate dehydrogenase (LDH) levels and International Prognostic Index (IPI) score were significantly higher in MAGE-A3-positive patients (P = 0.025 and P = 0.004, respectively). Expression of MAGE-A3 was associated with poor response to treatment and a significantly shorter overall survival (P < 0.001). Our data address new information in the association of MAGE-A3 expression and poor prognosis in DLBCL patients.
本研究评估了MAGE - A3表达在28例弥漫性大B细胞淋巴瘤（DLBCL）患者中的预后价值。通过定量实时逆转录聚合酶链反应（PCR）评估的MAGE - A3表达与疾病晚期之间存在显著关联（P < 0.05）。MAGE - A3阳性患者的血清乳酸脱氢酶（LDH）水平升高和国际预后指数（IPI）评分显著更高（分别为P = 0.025和P = 0.004）。MAGE - A3的表达与治疗反应不佳和总生存期显著缩短相关（P < 0.001）。我们的数据揭示了MAGE - A3表达与DLBCL患者预后不良之间关联的新信息。
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