Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705, Korea.
Mol Biol Rep. 2012 May;39(5):5569-74. doi: 10.1007/s11033-011-1361-6. Epub 2011 Dec 20.
The aim of this study was to determine whether the functional mannose-binding lectin (MBL2) exon 1 codon 54 polymorphism (rs1800450) confers susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. A meta-analysis was conducted on the MBL2 codon 54 polymorphism across 21 comparative studies. Meta-analysis showed an association between the MBL2 codon 54 B allele and SLE in all study subjects [odds ratio (OR) = 1.298, 95% confidence interval (CI) = 1.154-1.459, P = 1.4 × 10(-5)]. Analysis after stratification by ethnicity indicated that the MBL2 codon 54 B allele is significantly associated with SLE in Europeans, Asian, and Africans (OR = 1.246, 95% CI = 1.062-1.462, P = 0.007; OR = 1.268, 95% CI = 1.049-1.532, P = 0.014; OR = 1.939, 95% CI = 1.269-2.962, P = 0.002, respectively). However, African Americans had a much lower prevalence of the T allele (5.8%) than any other populations studied, whereas Asians had the highest prevalence (16.2%). This meta-analysis confirms that the MBL2 codon 54 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent.
本研究旨在确定功能性甘露糖结合凝集素（MBL2）外显子 1 密码子 54 多态性（rs1800450）是否会使不同种族的人群易患系统性红斑狼疮（SLE）。对 MBL2 密码子 54 多态性的 21 项比较研究进行了荟萃分析。荟萃分析显示，MBL2 密码子 54 B 等位基因与所有研究对象的 SLE 之间存在关联[比值比（OR）=1.298，95%置信区间（CI）=1.154-1.459，P=1.4×10(-5)]。按种族分层分析表明，MBL2 密码子 54 B 等位基因与欧洲人、亚洲人和非洲人患 SLE 显著相关（OR=1.246，95%CI=1.062-1.462，P=0.007；OR=1.268，95%CI=1.049-1.532，P=0.014；OR=1.939，95%CI=1.269-2.962，P=0.002）。然而，非裔美国人的 T 等位基因（5.8%）的患病率明显低于任何其他研究人群，而亚洲人的患病率最高（16.2%）。这项荟萃分析证实，MBL2 密码子 54 多态性与不同种族人群的 SLE 易感性相关，且其患病率具有种族依赖性。
