Jaurand M C, Bernaudin J F, Bignon J
Unité INSERM 139, CHU Henri-Mondor, Maréchal-de-Lattre-de-Tassigny.
Rev Prat. 1990 Sep 11;40(20):1823-8.
Mesothelial cells are described in situ at the surface of the pleura. Their functions are discussed, in relation with the inflammatory response to different agents (infectious agents, mineral fibres...) and with the carcinogenic transformation, particularly in relation to asbestos exposure. The mechanisms of fibrogenesis, either symphysis or pleural plaques, are not clearly understood. The numerous studies now in progress on the different steps and mechanisms of mesothelial transformation and mesothelioma genesis are summarized focusing on the most recent cytogenetic and molecular biology findings.
间皮细胞在胸膜表面原位描述。讨论了它们的功能，涉及对不同因素（感染因子、矿物纤维等）的炎症反应以及致癌转化，特别是与接触石棉有关。纤维生成的机制，无论是粘连还是胸膜斑，目前尚不清楚。总结了目前正在进行的关于间皮转化和间皮瘤发生的不同步骤和机制的大量研究，重点关注最新的细胞遗传学和分子生物学发现。
