基础 FSH/LH 比值升高：预测年轻和高龄妇女 IVF 结局的标志物。
Elevated day 3 FSH/LH ratio: a marker to predict IVF outcome in young and older women.
机构信息
Assisted Reproduction Unit, Zekai Tahir Burak Women's Health Education and Research Hospital, A.Ayrancı, 06540 Ankara, Turkey.
出版信息
J Assist Reprod Genet. 2012 Mar;29(3):231-6. doi: 10.1007/s10815-011-9695-5. Epub 2011 Dec 20.
PURPOSE
To evaluate the value of elevated day 3 FSH/LH ratio in predicting IVF results in young and older women.
METHODS
One hundred seventy-four women with normal day 3 FSH levels undergoing IVF treatment were studied. Patients were divided into two groups according to basal FSH/LH ratio: Group 1(FSH/LH ≥3, n = 43) and Group 2 (FSH/LH <3, n = 131). The effects of FSH/LH ratio on IVF outcomes were compared. Also, the impact of elevated FSH/LH levels on younger (<35 years; n = 113) and older (≥35 years; n = 61) women was evaluated.
RESULTS
Group 1 had significantly lower mean day 3 LH levels (p = 0.001), lower number of oocytes retrieved (p = 0.004) and lower clinical pregnancy rate (p = 0.04). Older women with elevated FSH/LH ratio (n = 23) had significantly lower transferred good grade embryo counts (p = 0.04) and lower pregnancy rate (p = 0.03) versus older women with lower FSH/LH ratio. But in younger women treatment outcomes were similar in both subgroups.
CONCLUSION
Elevated day 3 FSH/LH ratio is useful in predicting IVF outcome in older women, but does not seem to be an accurate predictor in younger women.
目的
评估基础日 FSH/LH 比值升高在预测年轻和高龄妇女 IVF 结局中的价值。
方法
研究了 174 例基础 FSH 水平正常行 IVF 治疗的妇女。根据基础 FSH/LH 比值将患者分为两组：组 1（FSH/LH≥3，n=43）和组 2（FSH/LH<3，n=131）。比较了 FSH/LH 比值对 IVF 结局的影响。此外，还评估了升高的 FSH/LH 水平对年轻（<35 岁；n=113）和高龄（≥35 岁；n=61）妇女的影响。
结果
组 1 患者的平均基础日 3 LH 水平显著降低（p=0.001），获卵数显著减少（p=0.004），临床妊娠率显著降低（p=0.04）。基础 FSH/LH 比值升高的高龄妇女（n=23）的优质胚胎移植数量显著减少（p=0.04），妊娠率显著降低（p=0.03），而基础 FSH/LH 比值较低的高龄妇女的治疗结局相似。但在年轻妇女中，两个亚组的治疗结局相似。
结论
基础日 FSH/LH 比值升高可用于预测高龄妇女的 IVF 结局，但似乎不能作为年轻妇女的准确预测指标。
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