在接受促性腺激素释放激素类似物控制性卵巢刺激的患者中，第3天黄体生成素水平能否预测体外受精的成功率？
Does day 3 luteinizing-hormone level predict IVF success in patients undergoing controlled ovarian stimulation with GnRH analogues?
作者信息
Orvieto Raoul, Meltzer Simion, Rabinson Jacob, Gemer Ofer, Anteby Eyal Y, Nahum Ravit
机构信息
Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel.
出版信息
Fertil Steril. 2008 Oct;90(4):1297-300. doi: 10.1016/j.fertnstert.2007.10.058. Epub 2008 Feb 4.
To examine whether day 3 LH level or FSH-LH ratio predict IVF outcome, we studied patients with a favorable prognosis a priori undergoing controlled ovarian hyperstimulation (COH) with GnRH agonist (agonist group; n = 131) or antagonist (antagonist group; n = 137). Although LH level could not predict IVF outcome, patients undergoing COH using the GnRH antagonist or agonist protocols with FSH-LH ratios >2 or >3, respectively, achieved significantly lower pregnancy rates (11.1% vs. 27.7% and 8.3% vs. 31.9%, respectively).
为了研究第3天的促黄体生成素（LH）水平或促卵泡生成素-促黄体生成素（FSH-LH）比值是否能预测体外受精（IVF）结局，我们预先研究了预后良好、接受促性腺激素释放激素（GnRH）激动剂（激动剂组；n = 131）或拮抗剂（拮抗剂组；n = 137）进行控制性卵巢刺激（COH）的患者。尽管LH水平不能预测IVF结局，但分别使用GnRH拮抗剂或激动剂方案且FSH-LH比值>2或>3的COH患者，其妊娠率显著降低（分别为11.1%对27.7%和8.3%对31.9%）。
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