Department of Food Science and Human Nutrition, Iowa State University, Ames, IA, USA.
Phytother Res. 2012 Jul;26(7):1048-52. doi: 10.1002/ptr.3698. Epub 2011 Dec 20.
A study was conducted in hamsters to determine if artichoke leaf extract (ALE) could lower plasma total and non-HDL cholesterol by increasing fecal excretion of neutral bile acids and sterols. Sixty-four Golden Syrian hamsters (8 week old) were fed control diet or a similar diet containing ALE (4.5 g/kg diet) for 6 weeks. No significant changes for total cholesterol, HDL, non-HDL cholesterol triglycerides or fecal neutral sterols and bile acids were found after 21 days for ALE-fed animals compared with controls. But after 42 days, ALE-fed male hamsters had significantly lower total cholesterol (15%), non-HDL cholesterol (30%) and triglycerides (22%) and female hamsters fed ALE showed reductions of 15% for total cholesterol, 29% for non-HDL cholesterol and 29% for triglycerides compared with controls. Total neutral sterol and bile acids concentrations increased significantly by 50% and 53% in fecal samples of ALE fed males, and 82.4% and 25% in ALE fed females compared with controls. The ALE lowered hamster plasma cholesterol levels by a mechanism involving the greater excretion of fecal bile acids and neutral sterols after feeding for 42 days.
一项针对仓鼠的研究旨在确定朝鲜蓟叶提取物(ALE)是否可以通过增加粪便中性胆汁酸和固醇的排泄来降低血浆总胆固醇和非高密度脂蛋白胆固醇。64 只金色叙利亚仓鼠(8 周龄)喂食对照饮食或含有 ALE(4.5g/kg 饮食)的类似饮食 6 周。与对照组相比,喂食 ALE 的动物在 21 天后,总胆固醇、HDL、非 HDL 胆固醇、甘油三酯或粪便中性固醇和胆汁酸没有明显变化。但 42 天后,喂食 ALE 的雄性仓鼠的总胆固醇(15%)、非高密度脂蛋白胆固醇(30%)和甘油三酯(22%)显著降低,而雌性仓鼠的总胆固醇、非高密度脂蛋白胆固醇和甘油三酯分别降低 15%、29%和 29%。与对照组相比,喂食 ALE 的雄性仓鼠粪便中的总中性固醇和胆汁酸浓度分别增加了 50%和 53%,而雌性仓鼠分别增加了 82.4%和 25%。ALE 通过在喂食 42 天后增加粪便胆汁酸和中性固醇的排泄来降低仓鼠的血浆胆固醇水平。