Jungi W F, Osterwalder B
Abteilung für Onkologie, Kantonsspital St. Gallen.
Schweiz Med Wochenschr. 1990 Sep 1;120(35):1273-9.
Metastases of an occult primary malignancy are quite common (5-10%), especially in lymph nodes, lung and bone. The search for the unknown primary is an intellectual challenge. Thorough history, meticulous physical examination, and economically and carefully directed additional investigations are the best methods of detecting a treatable malignancy. Even extensive standardized work-up, using all available laboratory and imaging techniques, may miss the primary tumor quite often and unnecessarily burden patients with poor prognosis. Prognostically and therapeutically distinct subgroups must be treated differently.
隐匿性原发性恶性肿瘤的转移相当常见（5%-10%），尤其是在淋巴结、肺和骨。寻找未知的原发灶是一项智力挑战。详尽的病史、细致的体格检查以及经济且谨慎地进行针对性的额外检查，是检测可治疗恶性肿瘤的最佳方法。即便采用所有可用的实验室和影像学技术进行广泛的标准化检查，也常常会漏诊原发肿瘤，并且不必要地给预后不良的患者带来负担。在预后和治疗方面有明显差异的亚组必须采用不同的治疗方法。
