Vigeh Mohsen, Yunesian Masoud, Shariat Mamak, Niroomanesh Shireen, Ramezanzadeh Fateme
Department of Hazard Assessment, National Institute of Occupational Safety and Health, Kawasaki, Japan.
Women Health. 2011 Nov 30;51(8):724-38. doi: 10.1080/03630242.2011.633599.
Carbon monoxide pollution frequently occurs due to auto exhaust, industrial emissions, and/or cigarette smoke. Exogenous and endogenous carbon monoxide affects blood pressure; however, the relation of carbon monoxide exposure to pregnancy hypertension has not been systematically examined. For the present study the authors recruited a total of 2,707 apparently healthy, non-obese, non-smoking mothers, aged between 15 and 40 years, who had singleton births, and who lived within two miles of the selected air monitoring stations in Tehran, Iran, to study the relation of ambient carbon monoxide to pregnancy hypertension (>140 mmHg systolic and/or >90 mmHg diastolic after the 20th week of gestation). A relatively small but statistically significant elevation in mean postpartum diastolic blood pressure (mean ± SD, 69.5 ± 9.8 mmHg) was observed in the mothers' who were exposed to relatively high ambient carbon monoxide (mean = 14.1 ppm) compared to mothers exposed to lower carbon monoxide (mean = 1.8 ppm) concentrations (mean ± SD, 68.0 ± 8.3 mmHg, p < 0.01). The authors found twice the rate of pregnancy hypertension in the relatively higher carbon monoxide exposed mothers than the mothers with lower exposure (adjusted odds ratio = 2.02, 95% CI 1.35-3.03). Findings of the present study suggest that high level ambient carbon monoxide exposure is associated with pregnancy hypertension.
一氧化碳污染经常因汽车尾气、工业排放和/或香烟烟雾而发生。外源性和内源性一氧化碳都会影响血压；然而，一氧化碳暴露与妊娠高血压之间的关系尚未得到系统研究。在本研究中，作者共招募了2707名年龄在15至40岁之间、表面健康、非肥胖、不吸烟、单胎分娩且居住在伊朗德黑兰选定空气监测站两英里范围内的母亲，以研究环境一氧化碳与妊娠高血压（妊娠20周后收缩压>140 mmHg和/或舒张压>90 mmHg）之间的关系。与暴露于较低一氧化碳浓度（平均 = 1.8 ppm）的母亲相比，暴露于相对较高环境一氧化碳（平均 = 14.1 ppm）的母亲产后平均舒张压出现了相对较小但具有统计学意义的升高（平均值±标准差，69.5±9.8 mmHg）（平均值±标准差，68.0±8.3 mmHg，p<0.01）。作者发现，暴露于较高一氧化碳环境的母亲患妊娠高血压的几率是暴露于较低一氧化碳环境母亲的两倍（调整后的优势比 = 2.02，95%置信区间1.35 - 3.03）。本研究结果表明，高水平的环境一氧化碳暴露与妊娠高血压有关。
