Syed N I, Bulloch A G, Lukowiak K
Neuroscience Research Group, University of Calgary, Canada.
Science. 1990 Oct 12;250(4978):282-5. doi: 10.1126/science.2218532.
Most rhythmic behaviors such as respiration, locomotion, and feeding are under the control of networks of neurons in the central nervous system known as central pattern generators (CPGs). The respiratory rhythm of the pond snail Lymnaea stagnalis is a relatively simple, CPG-based behavior for which the underlying neural elements have been identified. A three-neuron network capable of generating the respiratory rhythm of this air-breathing mollusk has been reconstructed in culture. The intrinsic and network properties of this neural ensemble have been studied, and the mechanism of postinhibitory rebound excitation was found to be important for the rhythm generation. This in vitro model system enables a better understanding of the neural basis of rhythm generation.
大多数节律性行为，如呼吸、运动和进食，都受中枢神经系统中被称为中枢模式发生器（CPG）的神经元网络控制。池塘蜗牛椎实螺的呼吸节律是一种相对简单的、基于CPG的行为，其潜在的神经元件已被确定。一个能够产生这种呼吸空气的软体动物呼吸节律的三神经元网络已在培养物中重建。已经研究了这个神经集合的内在和网络特性，并且发现抑制后反弹兴奋机制对节律产生很重要。这个体外模型系统有助于更好地理解节律产生的神经基础。
