Chemical and Analytical Development, Novartis Pharmaceuticals Corporation, East Hanover, New Jersey 07936, USA.
J Org Chem. 2012 Jan 20;77(2):1095-100. doi: 10.1021/jo2024224. Epub 2012 Jan 3.
A diastereoselective rhodium-catalyzed arylation of N-(tert-butanesulfinyl)imines with sodium tetraarylborates is described. This method is general for constructing various chiral α-branched amines and 2-substituted pyrrolidines with high diastereoselectivity. A practical asymmetric approach to access chiral amines has been developed involving the use of air-stable Rh catalysts and reagents and in the absence of an external ligand.
描述了一种铑催化的 N-（叔丁基亚磺酰基）亚胺与四芳基硼酸钠的对映选择性芳基化反应。该方法可广泛用于构建各种手性α-支链胺和 2-取代吡咯烷，具有高对映选择性。开发了一种实用的不对称方法来获得手性胺，该方法涉及使用空气稳定的 Rh 催化剂和试剂，并且不需要外部配体。
