Gottwald L, Dukowicz A, Piekarski J, Misiewicz B, Spych M, Misiewicz P, Kazmierczak-Lukaszewicz S, Moszynska-Zielinska M, Cialkowska-Rysz A
Palliative Care Unit, Department of Palliative Medicine, Chair of Oncology, Medical University of Lodz, ul. Ciolkowskiego 2, 93-509 Lodz, Poland.
J Obstet Gynaecol. 2012 Jan;32(1):81-6. doi: 10.3109/01443615.2011.619672.
The aim of this study was to investigate the clinical features and prognosis in patients with gynaecological epithelial cancers metastasised to bones. A total of 26 patients were studied retrospectively. Clinical and pathological data were analysed along with a follow-up. It was found that the interval from primary diagnosis of cancer until bony relapse varied between 0 and 163 months (31.4 ± 36.8). Bone metastases were solitary in 11 cases and multifocal in 15 cases. A total of 14 patients demonstrated only bony metastases while 12 had both bony and non-bony metastases. The time to follow-up from the diagnosis of osseous relapse varied between 1 and 43 months (10.0 ± 10.4). During follow-ups, 13 patients died and 13 patients survived. In both univariate and multivariate analyses, synchronous non-bony metastases and symptomatic treatment without oncological therapy impaired prognosis. It was concluded that even in the presence of multiple bone metastases, some patients may benefit from radiotherapy, chemotherapy or a combination of both, rather than palliative care alone, providing they do not have additional soft tissue metastases.
