Dimakopoulos Y, Bogaerds A C B, Anderson P D, Hulsen M A, Baaijens F P T
Department of Biomedical Engineering , Eindhoven University of Technology, 5600 MB Eindhoven, The Netherlands.
Comput Methods Biomech Biomed Engin. 2012;15(11):1157-79. doi: 10.1080/10255842.2011.581238. Epub 2011 Dec 21.
We study the nonlinear interaction of an aortic heart valve, composed of hyperelastic corrugated leaflets of finite density attached to a stented vessel under physiological flow conditions. In our numerical simulations, we use a 2D idealised representation of this arrangement. Blood flow is caused by a time-varying pressure gradient that mimics that of the aortic valve and corresponds to a peak Reynolds number equal to 4050. Here, we fully account for the shear-thinning behaviour of the blood and large deformations and contact between the leaflets by solving the momentum and mass balances for blood and leaflets. The mixed finite element/Galerkin method along with linear discontinuous Lagrange multipliers for coupling the fluid and elastic domains is adopted. Moreover, a series of challenging numerical issues such as the finite length of the computational domain and the conditions that should be imposed on its inflow/outflow boundaries, the accurate time integration of the parabolic and hyperbolic momentum equations, the contact between the leaflets and the non-conforming mesh refinement in part of the domain are successfully resolved. Calculations for the velocity and the shear stress fields of the blood reveal that boundary layers appear on both sides of a leaflet. The one along the ventricular side transfers blood with high momentum from the core region of the vessel to the annulus or the sinusoidal expansion, causing the continuous development of flow instabilities. At peak systole, vortices are convected in the flow direction along the annulus of the vessel, whereas during the closure stage of the valve, an extremely large vortex develops in each half of the flow domain.
我们研究了一种主动脉心脏瓣膜的非线性相互作用,该瓣膜由有限密度的超弹性波纹小叶组成,附着在生理流动条件下的带支架血管上。在我们的数值模拟中,我们使用了这种结构的二维理想化表示。血流由时变压力梯度引起,该梯度模拟主动脉瓣的压力梯度,对应的峰值雷诺数等于4050。在这里,我们通过求解血液和小叶的动量与质量平衡,充分考虑了血液的剪切变稀行为以及小叶之间的大变形和接触。采用了混合有限元/伽辽金方法以及用于耦合流体和弹性域的线性间断拉格朗日乘子。此外,一系列具有挑战性的数值问题,如计算域的有限长度及其流入/流出边界应施加的条件、抛物型和双曲型动量方程的精确时间积分、小叶之间的接触以及部分区域的非协调网格细化等,都得到了成功解决。对血液速度和剪应力场的计算表明,小叶两侧都出现了边界层。沿着心室侧的边界层将具有高动量的血液从血管核心区域输送到瓣环或正弦扩张处,导致流动不稳定性不断发展。在收缩期峰值时,涡旋沿血管瓣环在流动方向上对流,而在瓣膜关闭阶段,在流动域的每一半中都会形成一个极大的涡旋。