Cheng Kuiyu, Akhtar Shehnaz, Lee Kwan Yong, Lee Sang-Wook
School of Mechanical Engineering, University of Ulsan, Ulsan, 44610, Republic of Korea.
Cardiovascular Center and Cardiology Division, Seoul St. Mary's Hospital, Seoul, Republic of Korea.
Sci Rep. 2025 Jan 25;15(1):3236. doi: 10.1038/s41598-025-86983-z.
This study employed large eddy simulation (LES) with the wall-adapting local eddy-viscosity (WALE) model to investigate transitional flow characteristics in an idealized model of a healthy thoracic aorta. The OpenFOAM solver pimpleFoam was used to simulate blood flow as an incompressible Newtonian fluid, with the aortic walls treated as rigid boundaries. Simulations were conducted for 30 cardiac cycles and ensemble averaging was employed to ensure statistically reliable results. Main hemodynamic parameters, such as velocity fields, turbulence intensity turbulent kinetic energy (TKE), oscillatory shear index (OSI) and wall shear stress (WSS), were analyzed throughout the circulatory system. Through 3D computational fluid dynamics (CFD) visualization, we explained the transition from laminar to turbulent flow and its development throughout the cardiac cycle. The results demonstrated that turbulence originates in the aortic arch following the peak systole phase and further develops in the aortic arch and descending aorta during the mid-deceleration and end-systole phases, with the maximum turbulence intensity exceeding 25%. WSS reached up to 30 Pa during the peak systole, with an average WSS of 6.5 Pa across the cardiac cycle. Low and oscillatory WSS were observed during diastole which can potentially contribute to the development of vascular diseases including, aortic dissection and atherosclerosis.
本研究采用带有壁适应局部涡粘性(WALE)模型的大涡模拟(LES),以研究健康胸主动脉理想化模型中的过渡流特性。使用OpenFOAM求解器pimpleFoam将血流模拟为不可压缩牛顿流体,主动脉壁视为刚性边界。进行了30个心动周期的模拟,并采用总体平均以确保统计上可靠的结果。在整个循环系统中分析了主要血流动力学参数,如速度场、湍流强度、湍动能(TKE)、振荡剪切指数(OSI)和壁面剪切应力(WSS)。通过三维计算流体动力学(CFD)可视化,我们解释了从层流到湍流的转变及其在心动周期中的发展。结果表明,湍流在收缩期末峰后起源于主动脉弓,并在减速中期和收缩期末在主动脉弓和降主动脉中进一步发展,最大湍流强度超过25%。收缩期峰值时WSS高达30 Pa,整个心动周期的平均WSS为6.5 Pa。在舒张期观察到低且振荡的WSS,这可能会促进包括主动脉夹层和动脉粥样硬化在内的血管疾病的发展。