Department of Chemistry, The Kellogg School of Science and Technology, The Scripps Research Institute, Scripps Florida, Jupiter, 33458, United States.
ACS Chem Biol. 2012 Jan 20;7(1):73-86. doi: 10.1021/cb200447r. Epub 2012 Jan 12.
RNAs are underexploited targets for small molecule drugs or chemical probes of function. This may be due, in part, to a fundamental lack of understanding of the types of small molecules that bind RNA specifically and the types of RNA motifs that specifically bind small molecules. In this review, we describe recent advances in the development and design of small molecules that bind to RNA and modulate function that aim to fill this void.
RNAs 是小分子药物或功能化学探针的未充分利用的靶点。这可能部分归因于对特异性结合 RNA 的小分子的类型和特异性结合小分子的 RNA 基序的类型缺乏基本了解。在这篇综述中，我们描述了旨在填补这一空白的特异性结合 RNA 并调节其功能的小分子的开发和设计的最新进展。
