Nikolić S, Vujosević M, Zerajev S, Dulović O
Srp Arh Celok Lek. 1990 Jan-Feb;118(1-2):23-8.
The results of virusologic and cytobiochemical evaluation of CSF and serum samples of four patients with acute viral meningitis (AVM), most probably induced by varicella zoster virus (VZV), are reported. In no case VZV infection was not cutaneously manifested. Aetiologic diagnosis was established according to the presence of specific anti VZV AVM, in spite of their presence in the sera. On samples detected by indirect enzyme immunoassay (EIA). Four different antibody indexes were used to prove that the antibodies were intrathecally synthesized. Other viral antibodies (HSV, mumps) were not evident in the CSF samples of the patients with VZV avm, in spite of their presence in the sera. On the other hand, anti VZV antibodies could not be identified in the CSF samples of the controls (AVM of other aetiology, meningism) in spite of their presence in the sera. A possible aetiologic link between anti VZV antibodies presence in the CSF samples and some neurologic syndromes is discussed.
报告了4例急性病毒性脑膜炎（AVM）患者脑脊液和血清样本的病毒学及细胞生化评估结果，这些患者很可能由水痘带状疱疹病毒（VZV）引起。在所有病例中，VZV感染均无皮肤表现。尽管血清中存在特异性抗VZV抗体，但根据其存在情况仍确立了病因诊断。通过间接酶免疫测定（EIA）在样本中检测到。使用四种不同的抗体指数来证明抗体是鞘内合成的。尽管VZV AVM患者血清中存在其他病毒抗体（HSV、腮腺炎），但在其脑脊液样本中未检测到。另一方面，尽管对照组（其他病因的AVM、假性脑膜炎）血清中存在抗VZV抗体，但在其脑脊液样本中未检测到。讨论了脑脊液样本中抗VZV抗体的存在与某些神经综合征之间可能的病因联系。
