Chakraborty Susmita, Chakraborty Jayanta, Mandal Srikrishna, Ghosal Malay Kumar
IPGME&R, Kolkata 700020.
J Indian Med Assoc. 2011 May;109(5):345-6.
Valproic acid, a conventional antiepileptic drug, is also used in the treatment of bipolar disorder, to provide rapid stabilization of the patient. Although thrombocytopenia is a potential threat, occurrence of suppression of the other cell lines in the bone marrow is also found rarely. Here in this study we report a case of a 28 year old female treated with valproic acid and risperidone for bipolar disorder, who developed isolated neutropenia within 6 months of commencement of therapy that got reversed soon after termination of valproic acid therapy. This finding lays further emphasis on regular monitoring of all cell lines in blood for better management and to prevent any serious bone marrow toxicity in the patients.
丙戊酸是一种传统的抗癫痫药物，也用于治疗双相情感障碍，以实现患者的快速病情稳定。虽然血小板减少是一个潜在威胁，但骨髓中其他细胞系受抑制的情况也很少见。在本研究中，我们报告了一例28岁女性，她因双相情感障碍接受丙戊酸和利培酮治疗，在治疗开始后6个月内出现了单纯性中性粒细胞减少，在丙戊酸治疗终止后很快恢复。这一发现进一步强调了定期监测血液中所有细胞系对于更好地管理患者以及预防任何严重骨髓毒性的重要性。
