Lamy O, Metzger M, Krieg M-A, Aubry-Rozier B, Stoll D, Hans D
Service de médecine interne, Départment de médecine, CHUV, 1011 Lausanne.
Rev Med Suisse. 2011 Nov 2;7(315):2130, 2132-4, 2136.
OsteoLaus is a cohort of 1400 women 50 to 80 years living in Lausanne, Switzerland. Clinical risk factors for osteoporosis, bone ultrasound of the heel, lumbar spine and hip bone mineral density (BMD), assessment of vertebral fracture by DXA, and microarchitecture evaluation by TBS (Trabecular Bone Score) will be recorded. TBS is a new parameter obtained after a re-analysis of a DXA exam. TBS is correlated with parameters of microarchitecture. His reproducibility is good. TBS give an added diagnostic value to BMD, and predict osteoporotic fracture (partially) independently to BMD. The position of TBS in clinical routine in complement to BMD and clinical risk factors will be evaluated in the OsteoLaus cohort.
OsteoLaus队列由1400名年龄在50至80岁之间、居住在瑞士洛桑的女性组成。将记录骨质疏松症的临床风险因素、足跟骨超声、腰椎和髋部骨矿物质密度（BMD）、通过双能X线吸收法（DXA）评估椎体骨折以及通过小梁骨评分（TBS）进行微结构评估。TBS是在对DXA检查进行重新分析后获得的一个新参数。TBS与微结构参数相关。其可重复性良好。TBS为BMD提供了额外的诊断价值，并（部分）独立于BMD预测骨质疏松性骨折。将在OsteoLaus队列中评估TBS在补充BMD和临床风险因素的临床常规中的地位。
