Walter Reed National Military Medical Center, Bethesda, MD 20889-5600, USA.
Br J Dermatol. 2012 May;166(5):934-7. doi: 10.1111/j.1365-2133.2011.10794.x.
Granulomatous cheilitis (GC) is a poorly understood disease process belonging to the larger group of orofacial granulomatosis. The treatment of GC has proven exceedingly difficult. While various treatments have been applied to GC, there has been no uniform or predictably successful model demonstrated in the literature. Poor understanding of the aetiological mechanisms underpinning GC has significantly hampered the development of an effective approach to treatment. Those therapies that have shown promise principally consist of agents with anti-inflammatory activity such as corticosteroids and immunomodulatory medications. On a careful review of the literature, we have found no systematic review and assessment of current treatments. We seek to address this absence in the available literature by providing a consolidated overview of current treatment for GC.
肉芽肿性唇炎（GC）是一种发病机制尚不完全明确的疾病，属于口腔颌面部肉芽肿性疾病的一大类。GC 的治疗极具挑战性。尽管已经尝试了多种治疗方法，但文献中尚未展示出统一或可预测的有效治疗模式。由于对 GC 发病机制的认识不足，严重阻碍了有效治疗方法的发展。那些有希望的治疗方法主要包括具有抗炎活性的药物，如皮质类固醇和免疫调节药物。在对文献进行仔细审查后，我们没有发现对当前治疗方法的系统评价和评估。我们试图通过提供 GC 目前治疗方法的综合概述来解决现有文献中的这一空白。
