Department of Urology, Tokai University Hachioji Hospital, Hachioji, Tokyo, Japan.
Int J Urol. 2012 Mar;19(3):187-201. doi: 10.1111/j.1442-2042.2011.02936.x. Epub 2011 Dec 21.
Recent advances in high-intensity focused ultrasound, which was developed in the 1940s as a viable thermal tissue ablation approach, have increased its popularity. High-intensity focused ultrasound is currently utilized the most in Europe and Japan, but has not yet been approved by the Food and Drug Administration, USA, for this indication. The purpose of the present report is to review the scientific foundation of high-intensity focused ultrasound technology and the clinical outcomes achieved with commercially available devices. Recently published articles were reviewed to evaluate the current status of high-intensity focused ultrasound as a primary or salvage treatment option for localized prostate cancer. Improvements in the clinical outcome as a result of technical, imaging and technological advancements are described herein. A wide range of treatment options for organ-confined prostate cancer is available. However, high-intensity focused ultrasound is an attractive choice for men willing to choose less invasive options, although establishing the efficacy of high-intensity focused ultrasound requires longer follow-up periods. Technological advances, together with cultural and economic factors, have caused a dramatic shift from traditional open, radical prostatectomy to minimally invasive techniques. High-intensity focused ultrasound is likely to play a significant role in the future of oncology practice.
高强度聚焦超声技术的最新进展使其在 20 世纪 40 年代作为一种可行的热组织消融方法得到了广泛的应用。高强度聚焦超声目前在欧洲和日本应用最为广泛，但尚未获得美国食品和药物管理局(FDA)的这一适应证批准。本报告的目的是回顾高强度聚焦超声技术的科学基础和商业上可用设备所取得的临床结果。我们查阅了最近发表的文章，以评估高强度聚焦超声作为局限性前列腺癌的一线或挽救性治疗选择的现状。本文描述了技术、成像和技术进步带来的临床结果的改善。目前有多种治疗局限性前列腺癌的方法可供选择。然而，对于愿意选择侵入性较小的治疗方法的患者来说，高强度聚焦超声是一种有吸引力的选择，尽管高强度聚焦超声的疗效需要更长的随访时间来确定。技术进步，以及文化和经济因素，已经导致从传统的开放性、根治性前列腺切除术向微创技术的巨大转变。高强度聚焦超声很可能在肿瘤学实践的未来发挥重要作用。
