Hospital Universitario de Canarias, Department of Cardiology, Tenerife, Spain.
Biomarkers. 2012 Mar;17(2):134-9. doi: 10.3109/1354750X.2011.643486. Epub 2011 Dec 22.
Neopterin serum concentration increases in the presence of renal dysfunction.
We sought to determine the relationship between admission serum neopterin levels and worsening renal function (WRF) in patients with heart failure (HF).
We prospectively measured serum neopterin levels in patients with HF and the patients were subdivided into two groups: with and without WRF during hospital admission.
Logistic regression analysis showed that high serum neopterin levels at admission were associated with a greater likelihood of developing WRF.
Patients admitted to hospital with HF, elevated serum neopterin levels are associated with an increased risk of developing WRF.
血清中新蝶呤浓度在肾功能障碍时增加。
我们旨在确定心力衰竭（HF）患者入院时血清中新蝶呤水平与肾功能恶化（WRF）之间的关系。
我们前瞻性地测量了心力衰竭患者的血清中新蝶呤水平，并将患者分为两组：住院期间有和无 WRF。
Logistic 回归分析显示，入院时的高血清新蝶呤水平与发生 WRF 的可能性更大相关。
患有 HF 住院的患者，血清中新蝶呤水平升高与发生 WRF 的风险增加相关。
