Wilson S, Howard M A, Rossen J D, Brennan T J, Dalm B D, Dahdaleh N S, Utz M, Gillies G T
Department of Neurosurgery, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, Iowa 52242, USA.
J Med Eng Technol. 2012 Jan;36(1):22-5. doi: 10.3109/03091902.2011.632061.
We have designed, built and tested a novel spinal cord surrogate that mimics the low-amplitude cardiac-driven pulsations of the human spinal cord, for use in developing intradural implants to be used in a novel form of neuromodulation for the treatment of intractable pain and motor system dysfunction. The silicone surrogate has an oval cross section, 10 mm major axis × 6 mm minor axis, and incorporates a 3 mm diameter × 3 cm long angioplasty balloon that serves as the pulsation actuator. When pneumatically driven at 1 Hz and 1.5 atmospheres (≈ 1140 mm Hg), the surrogate's diametric pulsation is ≈ 100 μm, which corresponds well to in vivo observations. The applications for this surrogate are presented and discussed.
我们设计、制造并测试了一种新型脊髓替代物，它模拟了人类脊髓由心脏驱动的低振幅脉动，用于开发硬膜内植入物，以用于一种新型神经调节方式来治疗顽固性疼痛和运动系统功能障碍。该硅胶替代物的横截面为椭圆形，长轴10毫米×短轴6毫米，并包含一个直径3毫米×长3厘米的血管成形术球囊，作为脉动驱动器。当以1赫兹和1.5个大气压（≈1140毫米汞柱）进行气动驱动时，替代物的直径脉动约为100微米，这与体内观察结果非常吻合。本文介绍并讨论了这种替代物的应用。
