Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa-city, Ishikawa, Japan.
Neurobiol Aging. 2012 Oct;33(10):2321-3. doi: 10.1016/j.neurobiolaging.2011.11.020. Epub 2011 Dec 20.
Apolipoprotein E (ApoE) ε4 is known as a genetic risk factor for Alzheimer's disease (AD). This study investigated the prevalence of imaging abnormalities suggestive of AD in cognitively normal ApoE ε4 carriers using (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and voxel-based morphometry (VBM). Forty-five cognitive normal ApoE ε4 allele carriers and 45 noncarriers underwent both FDG positron emission tomography and magnetic resonance imaging (MRI). A total of 90 normal database sets were generated for the individual 45 ε4 carriers and 45 noncarriers. Mean z-scores in the predefined AD-specific regions of interest (ROI) were calculated for each ε4 carrier and noncarrier using the individually defined normal database. The prevalence of AD-like hypometabolism and atrophy in the ε4 carriers was 8.9% and 17.7%, respectively, and did not differ significantly from those in the noncarriers (8.9%, 8.8%). The majority of ε4 carriers showed preserved FDG uptake or gray matter concentration.
载脂蛋白 E (ApoE) ε4 被认为是阿尔茨海默病 (AD) 的遗传风险因素。本研究使用 (18)F-氟脱氧葡萄糖 (FDG) 正电子发射断层扫描 (PET) 和基于体素的形态计量学 (VBM) ，调查了认知正常的 ApoE ε4 携带者中提示 AD 的影像学异常的患病率。45 名认知正常的 ApoE ε4 等位基因携带者和 45 名非携带者接受了 FDG 正电子发射断层扫描和磁共振成像 (MRI)。为每个 ε4 携带者和非携带者分别生成了 90 个正常数据库集。使用个体定义的正常数据库，为每个 ε4 携带者和非携带者计算了预定义的 AD 特异性感兴趣区 (ROI) 中的平均 z 分数。ε4 携带者的 AD 样代谢低下和萎缩的患病率分别为 8.9%和 17.7%，与非携带者 (8.9%，8.8%) 无显著差异。大多数 ε4 携带者的 FDG 摄取或灰质浓度保持正常。
