新型组胺 H4 受体拮抗剂的合成。
Synthesis of novel histamine H4 receptor antagonists.
机构信息
Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, Sandwich, Kent CT13 9NJ, United Kingdom.
出版信息
Bioorg Med Chem Lett. 2012 Jan 15;22(2):1156-9. doi: 10.1016/j.bmcl.2011.11.098. Epub 2011 Dec 1.
PMID:22189138
Abstract
This letter describes the discovery and synthesis of a series of octahydropyrrolo[3,4-c]pyrrole based selective histamine hH4 receptor antagonists. The amidine compound 20 was found to be a potent and selective histamine H4 receptor antagonist with moderate clearance and a high volume of distribution.
摘要
这封信描述了一系列基于八氢吡咯并[3,4-c]吡咯的选择性组氨酸 hH4 受体拮抗剂的发现和合成。酰胺化合物 20 被发现是一种有效的、选择性的组胺 H4 受体拮抗剂，具有中等的清除率和高分布容积。
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