在青少年型原发性开角型青光眼中使用方差成分连锁分析检测多效性和上位性。
Detecting pleiotropy and epistasis using variance components linkage analysis in jPAP.
作者信息
Hasstedt Sandra J, Thomas Alun
机构信息
Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA.
出版信息
Hum Hered. 2011;72(4):258-63. doi: 10.1159/000331690. Epub 2011 Dec 23.
Abstract
jPAP (Java Pedigree Analysis Package) performs variance components linkage analysis of either quantitative or discrete traits. Multivariate linkage analysis of two or more traits (all quantitative, all discrete, or any combination) allows the inference of pleiotropy between the traits. The inclusion of multiple quantitative trait loci in linkage analysis allows the inference of epistasis between loci. A user-friendly graphical user interface facilitates the usage of jPAP.
摘要
jPAP（Java谱系分析包）对定量或离散性状进行方差成分连锁分析。对两个或多个性状（全为定量、全为离散或任意组合）进行多变量连锁分析可推断性状间的多效性。在连锁分析中纳入多个数量性状基因座可推断基因座间的上位性。用户友好的图形用户界面便于jPAP的使用。
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