低出生体重儿在首次到基层保健单位时接种卡介苗的小型随机试验。
Small randomized trial among low-birth-weight children receiving bacillus Calmette-Guérin vaccination at first health center contact.
机构信息
Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau.
出版信息
Pediatr Infect Dis J. 2012 Mar;31(3):306-8. doi: 10.1097/INF.0b013e3182458289.
A total of 105 low-birth-weight children presenting for first vaccination were randomized to receive bacillus Calmette-Guérin (BCG) immediately or later (current practice). The mortality rate ratio for BCG was 0.17 (95% CI = 0.02-1.35) within 3 days of enrollment, 0.28 (0.06-1.37) in the first month, and 0.27 (0.07-0.98) after 2 months of age. The mortality rate ratio was 0.41 (0.14-1.18) (P = 0.098) in infancy. Administration of BCG vaccine at first contact may contribute to lower mortality.
共有 105 名低出生体重儿在首次接种时被随机分为立即接种卡介苗（BCG）组和延迟接种组（当前做法）。在登记后 3 天内，BCG 组的死亡率比值为 0.17（95%CI=0.02-1.35），第 1 个月为 0.28（0.06-1.37），2 个月后为 0.27（0.07-0.98）。在婴儿期，BCG 疫苗的死亡率比值为 0.41（0.14-1.18）（P=0.098）。首次接触时接种 BCG 疫苗可能有助于降低死亡率。
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