Johnjulio William, Fuge Ladonna H, Kad Manjusha, Post Christopher
Department of Family Medicine, West Penn Allegheny Health System, Pittsburgh, PA, USA.
South Med J. 2012 Jan;105(1):24-9. doi: 10.1097/SMJ.0b013e31823c3ee4.
The management of common infections in family medicine can be complicated by poor treatment response or infection recurrence. Bacteria can grow as free-floating, planktonic bacteria or complex communities called biofilms. Biofilms promote bacterial growth and diversity and offer unique environments, including both aerobic and anaerobic layers, to bacteria. Although most treatments are tested against planktonic bacteria grown in the laboratory, infections in patients usually are the more complex and difficult to treat biofilms. Biofilms offer bacteria enhanced resistance to antimicrobial therapies that may otherwise be effective against planktonic bacteria. In many cases, difficulty treating recurring and recalcitrant infections can be explained by the important role of biofilms.
家庭医学中常见感染的管理可能会因治疗反应不佳或感染复发而变得复杂。细菌可以以自由漂浮的浮游细菌形式生长,也可以形成称为生物膜的复杂群落。生物膜促进细菌生长和多样性,并为细菌提供独特的环境,包括需氧层和厌氧层。尽管大多数治疗方法是针对实验室中培养的浮游细菌进行测试的,但患者身上的感染通常是更复杂且难以治疗的生物膜感染。生物膜使细菌对抗菌疗法具有更强的抵抗力,而这些疗法原本可能对浮游细菌有效。在许多情况下,复发性和顽固性感染难以治疗可以用生物膜的重要作用来解释。