German Cancer Research Center, DKFZ-ZMBH Alliance, Molecular Biology of Centrosomes and Cilia Unit, Heidelberg, Germany.
Cell Cycle. 2012 Jan 15;11(2):219-28. doi: 10.4161/cc.11.2.18857.
In budding yeast, the mitotic exit network (MEN) is a signaling pathway best known for its role in driving cells out of mitosis through activation of the conserved phosphatase Cdc14. However, work over the past few years show that MEN components and Cdc14 also have a direct role in promoting cytokinesis by acting upon components of the contractile actomyosin ring and cell separation machineries. In this review, we discuss the current view on the role of MEN kinases and Cdc14 in cytokinesis and comment on the cytokinesis-related function of MEN and Cdc14 orthologs in higher eukaryotes.
在芽殖酵母中，有丝分裂退出网络（MEN）是一条信号通路，其最著名的作用是通过激活保守的磷酸酶 Cdc14 来驱动细胞退出有丝分裂。然而，过去几年的工作表明，MEN 成分和 Cdc14 也通过作用于收缩肌动球蛋白环和细胞分离机制的成分，直接参与促进胞质分裂。在这篇综述中，我们讨论了 MEN 激酶和 Cdc14 在胞质分裂中的作用的最新观点，并评论了高等真核生物中 MEN 和 Cdc14 同源物与胞质分裂相关的功能。
