MMWR Morb Mortal Wkly Rep. 2011 Dec 23;60(50):1697-700.
On September 29, 2011, the United Network for Organ Sharing notified CDC of two patients who tested positive for hepatitis C virus (HCV) infection approximately 6 months after receiving kidney transplants from a deceased donor. Before transplantation, the donor had tested negative for HCV antibody by the organ procurement organization. Tissue also was procured from the donor for possible transplantation. The tissue bank performed an HCV antibody test on the donor's serum specimen that was negative and nucleic acid testing (NAT) that was positive, but misread as negative. Retesting of the donor specimen during the investigation confirmed the NAT results as positive. Donated tissue included 43 musculoskeletal grafts and one cardiopulmonary patch, which were distributed to health-care facilities in several states. An investigation was initiated to 1) identify potential sources of the donor's infection, 2) document the mode of transmission to the organ recipients, and 3) ensure timely notification of the implanting surgeons and testing of tissue recipients. Implantation of infected HCV tissue occurred after recognition of new HCV infection in the organ transplant recipients, highlighting the need for rapid communication between transplant centers, organ procurement organizations, tissue banks, and public health authorities regarding suspected transplantation transmission events.
2011 年 9 月 29 日，美国器官共享联合网络向疾病预防控制中心通报了两例患者的情况，这两例患者在接受一位已故供体的肾脏移植后约 6 个月，经检测 HCV 病毒（HCV）呈阳性。在移植前，供体的器官采购组织对 HCV 抗体检测呈阴性。还从供体处采集了组织，以备可能进行移植。组织库对供体的血清样本进行了 HCV 抗体检测，结果为阴性，核酸检测（NAT）结果为阳性，但误读为阴性。在调查过程中对供体样本进行了重新检测，结果证实了 NAT 检测结果为阳性。捐献的组织包括 43 个肌肉骨骼移植物和一个心肺补片，这些组织被分发给了几个州的医疗机构。发起调查的目的是：1）确定供体感染的潜在来源；2）记录传播给器官受者的方式；3）确保及时通知植入外科医生并对组织受者进行检测。在确认器官移植受者新感染 HCV 后，对受感染 HCV 组织进行了移植，这突显了移植中心、器官采购组织、组织库和公共卫生当局之间就疑似移植传播事件进行快速沟通的必要性。
