Fasmer O B
Psykiatrisk avdeling, Vestfold sentralsykehus, Tønsberg.
Tidsskr Nor Laegeforen. 1990 Aug 10;110(18):2370-2.
Patients with chronic pain are often depressed, and antidepressants have been widely used in the treatment of these patients. Well controlled clinical studies have shown that antidepressants have analgesic effects, apparently independent of changes in mood, and in lower doses than used in the treatment of depression. Good results have been reported for several types of chronic pain, especially headache and facial pain, arthritis, fibromyalgia and neuralgias. In addition, antidepressants have also an indirect analgesic action by relieving a depressive condition associated with chronic pain.
慢性疼痛患者常伴有抑郁情绪，抗抑郁药已广泛用于此类患者的治疗。严格对照的临床研究表明，抗抑郁药具有镇痛作用，这种作用显然独立于情绪变化，且使用剂量低于治疗抑郁症时的剂量。已有报道称，抗抑郁药对几种慢性疼痛疗效良好，尤其是头痛、面部疼痛、关节炎、纤维肌痛和神经痛。此外，抗抑郁药还可通过缓解与慢性疼痛相关的抑郁状态发挥间接镇痛作用。
