School of Life Science, Wuchang University of Technology, Wuhan, Hubei Province, People's Republic of China.
Biol Trace Elem Res. 2012 Jun;147(1-3):240-5. doi: 10.1007/s12011-011-9302-8. Epub 2011 Dec 22.
The interactions between selenium (sodium selenite), anthracycline antibiotics daunorubicin (DNR), and major contractile protein cardiac myosin (CM) were investigated. The results showed that the binding force between selenium and CM was 100 times stronger than that of DNR and CM. There was no marked influence on fluorescence intensity of DNR-CM at selenium concentrations of up to 20 μM. The co-administration of selenium (0.5-10.0 μg Se/ml) together with DNR resulted in a significant reduction in mice cardiotoxicity. However, selenium at the dose of 50.0 or 100.0 μg Se/ml afforded no obvious protection. The data indicate that selenium in the form of sodium selenite at appropriate dosage (<10.0 μg Se/ml) diminish the cardiac toxicity of DNR, potentially allowing the use of DNR at higher dosages in clinical cancer chemotherapy.
研究了硒（亚硒酸钠）、蒽环类抗生素柔红霉素（DNR）和主要收缩蛋白肌球蛋白（CM）之间的相互作用。结果表明，硒与 CM 的结合力比 DNR 与 CM 的结合力强 100 倍。在硒浓度高达 20 μM 时，DNR-CM 的荧光强度没有明显影响。联合使用硒（0.5-10.0 μg Se/ml）和 DNR 可显著降低小鼠的心脏毒性。然而，硒剂量为 50.0 或 100.0 μg Se/ml 时则没有明显的保护作用。数据表明，亚硒酸钠形式的硒在适当剂量（<10.0 μg Se/ml）下可降低 DNR 的心脏毒性，可能使 DNR 在临床癌症化疗中以更高剂量使用。
