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纳米混悬剂研发的小型综述。

A mini review of nanosuspensions development.

机构信息

Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan, PR China.

出版信息

J Drug Target. 2012 Apr;20(3):209-23. doi: 10.3109/1061186X.2011.645161. Epub 2011 Dec 23.

Abstract

Nanosuspension drug delivery has obtained great success in the preparation of insoluble drugs. The nanosuspension technology can confer a series of special characteristics to the drugs, such as the enhanced dissolution rate and saturation solubility. This mini review first described the differences between the nanocrystals and nanosuspensions. Next, the product techniques, the stable measures, the special features, and the routes of administration of the nanosuspensions were reviewed and compared. Finally, some existing shortcomings of the nanosuspensions were mentioned and the perspectives of the nanosuspensions were also made.

摘要

纳米混悬剂给药在制备难溶性药物方面取得了巨大成功。纳米混悬剂技术可以赋予药物一系列特殊性质,如提高溶解速率和饱和溶解度。本综述首先描述了纳米晶体和纳米混悬剂之间的差异。接下来,对纳米混悬剂的制剂技术、稳定措施、特殊性质和给药途径进行了综述和比较。最后,提到了纳米混悬剂存在的一些缺点,并对纳米混悬剂的前景进行了展望。

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